CO2RE Intima

What can you treat with CO2RE Intima*?

  • CO2RE Intima is a module of the CO2RE System
  • Treats Dyschromia and Skin Pigmentation
  • Warts

What will patients experience?

  • A safe, quick and easy in-office procedure
  • Non-surgical, incisionless
  • 10 to 15 min treatment
  • Mild to no discomfort


What is CO2RE Intima?
CO2RE Intima is a new, in-office, non-surgical treatment that uses laser energy in gynecological applications. CO2RE Intima is a medical laser that delivers controlled CO2 energy to the tissue improving skin tone, texture and appearance.

What are CO2RE’s FDA clearances?
CO2RE is FDA cleared for more than 90 indications for use across an array of medical specialties including aesthetic surgery (dermatology and plastic surgery), and gynecology, among others. In the dermatology and plastic surgery specialties, CO2RE is indicated for, among other applications: “clinical literature demonstrates that skin resurfacing of wrinkles, rhytids and furrows with CO2 laser increases the amount of sub-epidermal collagen.”2 The full list of FDA clearances for CO2RE is available from your Syneron Candela sales representative.

What conditions does CO2RE Intima treat?
In the gynecology specialty, CO2RE performs laser incision, excision, ablation and/or vaporization of soft tissue, for treatment of condylomas, vulvar dystrophies, and benign lesions of external genitalia. It is used for treating uneven pigmentation, to reduce dyschromia.

What are the features that make CO2RE a smart investment?
The versatility of the CO2RE laser allows for a comprehensive rejuvenation technique from fractional to full resurfacing and a surgical mode for excision or incision of tissue. CO2RE is a versatile platform, which offers proven solutions for skin resurfacing, wrinkle and scar reduction, pigmentation, minor dermal incisions and excisions, and now gynecological treatments. CO2RE, which employs an RF-excited, digital super pulsed CO2 laser, gives physicians the ability to treat both superficial and deep skin layers simultaneously with precision control over the intensity, pattern and depth of ablation. The CO2RE Intima expands your treatment options by expanding your practice to gynecological applications. CO2 laser treatment has been well studied over many years for its effects on human tissue, and it remains the current gold-standard for tissue rejuvenation. The CO2RE laser is exceptionally versatile and comfortable to use in the treatment of a spectrum of genitourinary pathology involving the skin and soft tissues.

Why is an RF-excited, digital super pulsed CO2 better than those which are DC-excited?
The RF-excited digital super pulsed CO2 laser of CO2RE delivers a smooth top hat pulse with better ablation-coagulation ratio for optimal results. DC-excited CO2 lasers deliver pulses with non-ablative emission tails, which can result in less optimum ablation-coagulation ratio and in patient discomfort.

How do CO2 lasers compare to Erbium YAG lasers?
As compared to Erbium YAG lasers, which cause tissue contraction as a normal part of the wound healing response, CO2 lasers stimulate collagen via heat induced collagen contraction and subsequent stimulation. There is an increased risk of scarring seen in wound contracture, following Erbium YAG treatment, compared to heat induced collagen formation.3

What is the mechanism of action (MOA)?
CO2 lasers reach temperature thresholds for coagulation, contraction, denaturization and subsequent stimulation of collagen. Fibroblasts are found during the proliferation phase and subsequent histology reveals collagen remodeling and new deposition.

Why is CO2RE Intima different?
CO2RE Intima utilizes a CO2 laser, and includes an external handpiece for the external gynecological area. CO2 lasers have been proven to remodel tissue with neoformation of collagen and elastic fibers in atrophic skin.5 CO2 technology also provides physicians with the ability to treat both superficial and deep skin layers simultaneously and with the precision control they need over the intensity, pattern and depth of ablation, which is very important for treatments to the gynecological area.

Are there risks to laser treatment?
The CO2RE device has FDA clearance for a range of gynecological and genitourinary indications. CO2RE Intima is approved for gynecological applications. Patients experience mild to no discomfort, and with little downtime.

How many treatments does it take?
Patients receive three in-office treatments that are spaced ~3 weeks apart.

When will patients see results?
Most CO2RE Intima patients feel and see improvement after the very first treatment, although the procedure calls for three treatments.

How long does treatment last?
After the third treatment, patients should expect to come back annually for a maintenance treatment.

Can CO2RE Intima be used for modifying the appearance of the vulvar area?
The CO2RE Intima laser treatment can address some vulvar concerns. The treatment can also address dyschromia and skin pigmentation. The full list of FDA clearances for CO2RE is available from your Syneron Candela sales representative.

1 Clinical Study, HM Monteprincipe Hospital, Madrid, Spain, 2015 2 Direct quote from CO2RE FDA clearance. 3 Zerbinati N, Serati M, Origoni M, et al. Microscopic and ultrastructural modifications of postmenopausal atrophic vaginal mucosa after fractional carbon dioxide laser treatments. Lasers Med Sci (2015) 30:429-436. 4 MacBride MB, Rhodes DJ, Shuster LT. Vulvovaginal Atrophy. Mayo Clin Proc 2010;85:87-94 5 Salvatore, S, et al. Histological study on the effects of microablative fractional CO2 laser on atropic vaginal tissue: an ex vivo study. Menopause. 2015, Jan 20. (Epub ahead of print).